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Model Description (Ueda et al., 2001)
The model is comprised of per, tim and Clk mRNA and proteins, assuming constant concentration of the CYC protein. The gene expression is regulated by PER-TIM and CLK-CYC heterodimers that are transported to the nucleus.
ABSTRACT
A mechanism for generating circadian rhythms has been of major interest in recent years. After the discovery of per and tim, a model with a simple feedback loop involving per and tim has been proposed. However, it is recognized that the simple feedback model cannot account for phenotypes generated by various mutants. A recent report by Glossop, Lyons & Hardin [Science286, 766 (1999)] on Drosophila suggests involvement of another feedback loop by dClk that is interlocked with per-tim feedback loop. In order to examine whether interlocked feedback loops can be a basic mechanism for circadian rhythms, a mathematical model was created and examined. Through extensive simulation and mathematical analysis, it was revealed that the interlocked feedback model accounts for the observations that are not explained by the simple feedback model. Moreover, the interlocked feedback model has robust properties in oscillations. Copyright 2001 Academic Press.
Reference :
Ueda, H. R., Hagiwara, M., and Kitano, H. (2001).
"Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm. "
J Theor Biol 210, 401-406.
PubMed ID : 11403560
Model :
Zipped by E-Cell SE 3 >> [ Download ]
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