Assumptions for "robust" perfect adaptation

Two state model of receptor activation

two state model

• Chemoreceptors are in equilibrium between two conformaions(active/inactive).
• Receptors in the active conformation can stimulate CheA autophosphorylation.

"Robust" adaptation mechanism

robust adaptation mechanism

• Receptor methylation changes with the activiey of the receptors.
  • CheR only bind receptors in inactive conformation.
  • CheB only bind receptors in active conformation.